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Platelets play an important role in wound healing. They provide initial hemostasis and release mediators to help modulate the inflammatory response and many of the cellular functions involved in wound healing. Contained in the alpha granules of platelets are multiple growth factors, which would include PDGF, TGF, PDAF, PDEGF, EGF, TNF, LDGF, FGF, CTGF along with many others. Growth factors are proteins that impart specific biochemical messages to specific target cells through specific membrane receptors. Growth factors possess paracrine related properties which are stimulatory for mitogenic activities, cellular differentiation, protein transcription, chemotaxis, angiogenesis, and collagenase activities. Tissue repair begins with a clot formation and platelet degranulation which release the growth factors necessary for wound repair. The chemotactic and proliferative effects of these cytokines cause the migration of neutrophils and macrophages, adding an antimicrobial component to the wound site. Angiogenesis, fibroplasia, and collagen synthesis, caused by growth factors, lead to rapid re-epithelization and increased wound tensile strength. PDGF may also act as an exogenous source of growth factors to help stimulate the anabolic activity of bone cells. Osteoblast-like cells have been shown to be sensitive to the proliferative action of a wide variety of growth factors. These growth factors have been isolated from platelets and bone and are locally released in response to injury.